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[2017-12-29] 李光申博士,台北市立聯合醫院副總院長, "AI 在醫學應用之現況;挑戰與展望"

專題討論演講公告
張貼人:Seminar專用帳號2公告日期:2017-12-25

Title: AI 在醫學應用之現況;挑戰與展望
Date: 2017-12-29  02:20 pm-03:30pm
Location: R 103, CSIE
Speaker: 李光申博士,台北市立聯合醫院副總院長
Hosted by: Prof. Jia-Ling Wu

Abstract

Enhanced, more reliable, and better understood than in the past, artificial intelligence (AI) systems can make providing healthcare more accurate, affordable, accessible, consistent, and efficient. However, AI technologies have not been as well integrated into medicine as predicted so far. In order to succeed, medical and computational scientists must develop hybrid systems that can effectively and efficiently integrate the experience of medical care professionals with capabilities of AI systems.

The purpose of this talk is to introduce the current progress as well as challenges in the application of AI in medicine. It is hoped that, a cross-disciplinary collaboration can be fostered and established amongst experts with various backgrounds to substantiate the application of AI in medicine.

 

Biography

After obtaining medical degree and finishing residency training in orthopaedic surgery, I went to University College London, England for PhD study, where I used bone marrow mesenchymal stem cells (MSCs) isolated from bone marrow to treat severe nonunion fractures using animal models. After finishing my research training in England, I returned to Taiwan and started my own lab at the Taipei Veterans General Hospital in 2002. The major research theme is plasticity and application of MSCs. Being a clinician and a stem cell scientist, I am particularly interested in developing new application of MSCs to treat diseases that currently lack cures.

Over the years, I and my team members reported the successful isolation of multipotent MSCs from human bone marrow and umbilical cord blood capable of differentiating into different lineages. The multi-germ-layer differentiation potential was further demonstrated using an in utero transplantation model. We also reported the differentiation potential of MSCs into hepatocytes in vitro under defined conditions. Subsequently, the therapeutic potential of MSCs for treatment of liver disease was demonstrated using a mouse model of fulminant hepatic failure. To further look into the possibility of MSCs for bone tissue engineering, we studied the growth and differentiation of mesenchymal stem cells on Type 1 collagen nanofibers. In addition, molecular mechanisms and changes of mitochondrial biogenesis during osteogenic differentiation of MSCs have also been investigated. Other research achievements include the isolation of stem cells from human parathyroid gland, fat tissues and the cruciate ligaments of the knee joint. We have also studied the role of MSCs in the immune system and have successfully used MSCs to treat lupus nephritis in experimental animal model. Besides, biophysical effects of MSCs have also been investigated, and the molecular mechanisms governing matrix stiffness-induced differentiation of MSCs have been studied.

 

最後修改時間:2017-12-25 PM 5:29

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